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Ohio State Launches NanoInventio to Advance Super-Resolution Imaging Technology

The Ohio State University has launched NanoInventio Inc., a new university startup formed to commercialize advanced technology in Single Molecule Localization Microscopy (SMLM), a powerful imaging approach used to study biological systems at the molecular level. 

The technology was developed by Rengasayee (Sai) Veeraraghavan, professor in Ohio State’s Department of Biomedical Engineering, and gives scientists a clearer view of what is happening inside cells. That clearer view could accelerate the development of new therapies, improve disease detection and expand what is possible in biomedical research. 

At the core of the innovation is a novel, hyperparameter-free clustering method based on Voronoi tessellation, designed to analyze high-dimensional biological data without the need for manual tuning. The approach allows researchers to spend less time managing data and more time focused on discovery, with potential applications in biomedical research, diagnostics, and data-driven life sciences. 

"NanoInventio's technology is designed to provide scientists and engineers with easy and robust access to the nanoscale,” Verraghavan said.  “Our very existence and our technologies are a response to the technical challenges we have faced in the course of our own biomedical research, we share our target market's pains and have built solutions to address them." 

 

 Rengasayee (Sai) Veeraraghavan
Rengasayee (Sai) Veeraraghavan, professor in Ohio State’s Department of Biomedical Engineering

Ohio State executed a license agreement with NanoInventio that includes equity participation, milestone-based diligence obligations and provisions for domestic and foreign patent protection under the oversight of the Ohio State Innovation Foundation (OSIF). The technology is also governed by an inter-institutional agreement with Hunter College, which contributed to the invention, with revenue shared between the institutions. 

“NanoInventio reflects Ohio State’s commitment to translating research excellence into real-world impact,” said Kevin Taylor, chief innovation officer at Ohio State. “By supporting faculty innovators and providing a clear path to commercialization, we help ensure that discoveries made at Ohio State reach the researchers, clinicians and communities who can benefit from them.”